Constraint-based modeling is a powerful modeling methodology that is being used to model a diverse range of biological phenomena. These include both fundamental and applied questions relevant to biotechnology, microbiology and medicine. Central to constraint-based modeling is the use of genome-scale reconstructions that represent particular cellular functions as a biochemical reaction network. In this course, you will be introduced to:
- the principles of constraint-based reconstruction and analysis (COBRA)
- the underlying mathematical foundations of constraint-based modeling
- methods for integration of omics data with constraint-based models
- basic and advanced methods for interrogating models and interpreting results
- open source COBRA software, including the COBRA Toolbox
- standards for reconstruction and model sharing
- example applications to biomedicine and biotechnology
The course is structured into both lectures and practical sessions so that theory can be illustrated with biologically motivated computational examples.
Date: 18-22 November 2019
Location: Leiden University
