Constraint-based modelling: introduction and advanced topics

Constraint-based modeling is a powerful modeling methodology that is being used to model a diverse range of biological phenomena. These include both fundamental and applied questions relevant to biotechnology, microbiology and medicine. Central to constraint-based modeling is the use of genome-scale reconstructions that represent particular cellular functions as a biochemical reaction network. In this course, you will be introduced to:

  • the principles of constraint-based reconstruction and analysis (COBRA)
  • the underlying mathematical foundations of constraint-based modeling
  • methods for integration of omics data with constraint-based models
  • basic and advanced methods for interrogating models and interpreting results
  • open source COBRA software, including the COBRA Toolbox
  • standards for reconstruction and model sharing
  • example applications to biomedicine and biotechnology

The course is structured into both lectures and practical sessions so that theory can be illustrated with biologically motivated computational examples.

Date: 18-22 November 2019

Location: Leiden University

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