The course aims to introduce the student to the molecular principles and advanced technology for decoding nature’s molecular machines. The acquired knowledge provides a rationale for novel therapeutic interventions and applications in nano- and synthetic biology.
We will focus on the chemical principles underlying protein structure and function and how proteins fold and assemble into complex “molecular machines”. The students will be introduced to advanced methods in structural and molecular biology and biophysics for decoding the cellular protein machinery at atomic resolution. We will examine how malfunction of specific components can lead to systemic failure and disease. The school will combine theory (lectures, tutorials) with experiments in research laboratories.
Date: July 7-18, 2014
Target audience: Advanced bachelors / beginning masters in the early stage of their study with a background in chemistry, molecular biology or biophysics as well as proficiency in English.
Program: This course focuses on the chemical principles underlying protein structure and function and how proteins form an assembly of “molecular machines” that work together to sustain the living state. We will explore how proteins “know” what shape they should fold up into following their synthesis, how they cluster into dynamic macromolecular complexes, and how these complexes communicate to form “social” networks that enable cells to move, replicate, signal, and execute other vital processes. The students will be introduced to advanced methods in structural and molecular biology and biophysics for decoding the cellular protein machinery at atomic resolution, and examine how malfunction of specific components can lead to systemic failure and disease. The school will combine theory (lectures, tutorials) with experiments in research laboratories (including e.g. a 900 MHz NMR spectrometer, the Netherlands Proteomics Center and semi-automated protein crystallization facility). We also schedule a visit to a leading biotech company.
Course website: http://www.utrechtsummerschool.nl/courses/science/exploring-natures-molecular-machines
