Project: Research at Home
Alzheimer research is not just focusing on prevention and cure, but also on patients living with Alzheimer. As already 85% of the 250.000 Dutch Alzheimer patients live at home, a new research infrastructure is needed.
This infrastructure needs to connect a combination of digital appliances, care professionals, automated diagnostics and smart domotica. From analysing voices of patients and digital care logs to smartwatches with connected health apps.
The Personal Health Train could support this research offering a new type of research infrastructure. Personal lockers of data of Alzheimer patients can be created and “Trains” would fill these personal stations with information from the patient themselves, from general practitioners and care organizations. Researchers could send application to the stations to learn e.g. which domotica is most effective in which patients. Or to find which behaviour pattern changes are reliable indicators for the progression of Alzheimer. It is expected that “Research at Home” could not only enable new research but also make current research much less expensive.
The COMMIT Public Private ICT Research Community has issued a call for Swallow projects. These projects are intended to enable technology transfer from the current, almost finished COMMIT/Programme to the new public-private COMMIT2DATA programme (ICT-Topsector programming 2016-2019).
The Personal Health Train team co-authored the Privacy Respecting ANAlysis of Distributed patient health DATA (PRANA-DATA) project. This project with TNO (lead), Radboud University, Maastricht UMC+, UMC Groningen, Portavita, Synergetics, and DTL has been approved on January 21, 2016. The project will be led by Prof. Wessel Kraaij of TNO/Radboud University.
The Health Research Infrastructure initiative (Health-RI) aims to establish an interconnected data infrastructure for Dutch personalised medicine and health research. Health-RI is a joint initiative of DTL, ELIXIR-NL, BBMRI-NL, EATRIS-NL, NFU, and Health~Holland, supported by a large group of stakeholders in the health domain.
More info: https://www.health-ri.org/
STW Perspectief Programme
Radiomics is an image mining approach where vast amounts of features are extracted from medical images and correlated with biology and clinical outcome features (animation on: https://www.youtube.com/watch?v=Tq980GEVP0Y).
A STW Perspectief programme has been awarded to a consortium of public and private partners to develop the Radiomics approach further. The Personal Health Train team will lead the STW “Distributed Radiomics” project where a distributed FAIR infrastructure is set-up at four Dutch UMCs (Maastricht, Rotterdam, Groningen, Nijmegen) so that medical images can be mined without the need for these images to leave the hospital.
euroCAT and its sibling projects duCAT, chinaCAT, VATE, ozCAT (www.eurocat.info, https://www.youtube.com/watch?v=ZDJFOxpwqEA) : “Distributed learning to enable personalized medicine”.
The goals of the CAT network are:
a) to develop a distributed data infrastructure of cancer patients, tumours, images and treatments
b) learn outcome prediction models in a distributed manner.
The euroCAT infrastructure original spanned 5 radiotherapy centres in the Netherlands, Belgium and Germany and established FAIR data stations in hospitals and trains “avant la lettre”. The current network consists of 18 centres from the Netherlands, Belgium, Germany, UK, Italy, USA, Australia, India and China.
The CAT network is funded from a variety of global bodies including STW (NL), The Ministry of Health (NSW, Australia), Varian Medical Systems Inc (USA) and Interreg (EU).
KNAW-KRING: “Klinische data beschikbaar maken voor Researchers In een Nederlandse Grootschalige onderzoeksfaciliteit”. The Royal Netherlands Academy of Arts and Sciences has initiated a call for the best ideas for facilities that should be available in the Netherlands in 2025. The KRING project was selected for the final round and takes a similar approach the The Personal Health Train.
NWO-Personal Health Train: MUMC+, LUMC, UMCG and VUA came together to synthesize the Personal Health Train for the first time based on several disparate initiatives from these partners. Submitted to NWO-“Investeringen Groot”, it failed to meet the criteria for funding but started the journey of the Personal Health.