LUMC – Postdoc Human Genetics

The project you will work on focuses on Polycystic Kidney Disease (PKD). PKD is characterized by the formation of many fluid-filled cysts in the kidneys. The number and size of cysts increase over time, finally causing renal failure. The main focus of our research is to unravel the disease mechanism with the aim to develop therapies. To this aim mouse models, cell lines and organoids are being used with (tissue-specific) disruption of the gene involved, in combination with molecular biological, genetic and drug identification strategies. You will focus on functional effects of specific mutations in novel mouse and cell models, and the effects of drug treatments. You will apply molecular-biological techniques combined with cell biology, microscopic analyses and animal studies. Continue reading