AMC – COSMIC PhD position: Development of multiscale mathematical models of the germinal center to elucidate its role in B-cell lymphoma and/or rheumatoid arthritis

Background
EU countries face large health challenges to combat chronic diseases including immune disorders. Recently, systems medicine has emerged as a promising discipline to accelerate the translation of basic research into applications for improved diagnostics and personalized treatment. Its power arises from the integration of laboratory and computational approaches crossing research disciplines and sectors to solve biomedical and clinical questions.

Approach
COSMIC will focus on B-cell lymphoma (BCL) and rheumatoid arthritis (RA), prototypical diseases originating from abnormal functioning of immune cells. The PhD candidate will develop computational models of the germinal center (GC) at the cellular level and the underlying gene regulatory networks. Agent-based modelling and differential equations will be used to develop these models. These cellular and molecular models will be integrated into multiscale models to study the role of the GC in BCL and/or RA. In addition, we will use these models to determine the effect of molecular perturbations on the cellular level.

Our department
The Bioinformatics Laboratory of the Academic Medical Center Amsterdam focusses on system genomics and systems medicine approaches to address biomedical questions. For more information see (http://www.bioinformaticslaboratory.nl)

Your experience

  • Candidates should have a Master’s degree in computer sciences, bioinformatics, or similar with a strong interest in immunology and (molecular) biology.
  • Experience with differential equations and/or agent-based modelling
  • Basic statistical knowledge and experience with R
  • Strong programming skills in c++
  • Excellent higher education track record and strong scientific curiosity.
  • Fluent spoken and written English skills
  • Outstanding communication skills
  • In addition, the following experience would be helpful, but not essential:
  • Experience in OMICS data analysis and high performance computing.
  • Experience in systems biology or systems medicine.

We seek a highly motivated scientist who enjoys an interdisciplinary environment and in a interdisciplinary project. You are able to work independently but also as part of a team, and have strong communication skills.

Our offer
This position is funded by the Marie Skłodowska-Curie actions of the European Union’s Horizon 2020 research and innovation programme under grant agreement No 765158. The appointment is with AMC Medical Research (AMR), Amsterdam, The Netherlands.Under recruitment procedure the general MC salary description is detailed. Due to local law and differences in family situation, the exact salary will be determined in the host institution upon recruitment.

Your application
See recruitment procedure. You can apply using the online application form. For more information about the position you can contact prof. dr. Antoine van Kampen (a.h.vankampen@amc.uva.nl, +31-20-5667096)

AMC Medical Research (AMR)
AMC Medical Research offers numerous job opportunities within the field of scientific research. We offer challenging job opportunities in an internationally oriented environment with attractive employment conditions. We are committed to creating the right conditions to enable you to develop your talents in a stimulating, internationally oriented and inspiring environment. We aspire to help you become an authority in your specialty. For foreign nationals we provide assistance in applying for the tax benefit which the Dutch tax agency awards foreign nationals (under certain conditions), as a compensation for extraterritorial costs. If you are a non EU-resident we also assist you with all matters relating to your work permit.

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