The Huynen group at the Centre for Molecular and Biomolecular Informatics (CMBI, www.cmbi.ru.nl) offers a 2-year postdoc, with possibility for extension, for research in system vaccinology of Bordetella pertussis. B. pertussis infection levels and mortality levels are rising, necessitating research into new tools to assess the efficacy of new vaccines. Within the European Periscope project (http://periscope-project.eu/), which is funded by Innovative Medicines Initiative (IMI) and the Bill and Melinda Gates foundation, we collect molecular (RNAseq), cellular (Eurflow) and immunological data from multiple clinical trials to measure the response to vaccination and infection. The candidate has a strong bio-computational background and will do comparative analyses of these data in order to detect which short term molecular and cellular observables correlate with various immunological parameters like antibody levels and T-cell responses. That we have data from multiple, parallel trials, allows comparative analyses between them and with data from model species to derive robust models. Furthermore, the multidimensionality of the data allows e.g. de-convolution approaches to delineate the gene expression per cell type and detect the genes whose expression reflects a successful vaccination. The candidate will take a leading role in such comparative analyses and in their immunological interpretation and will communicate the results within the CMBI and with the Periscope consortium.
The CMBI is a bioinformatics centre that has a long experience in the comparative analysis of ‘omics data to obtain biological insights and prioritize experimental follow up. We offer a lively, international environment driven by curiosity and high quality science.
- Ph.D. with a proven track record in computational biology / bioinformatics and (preferred)immunology, molecular biology or related areas.
- Proficient in large-scale dataset analysis (e.g. RNA-seq and proteomics data) and experienced in programming.
- A vision to go beyond first order analyses of ‘omics data to translate them into biological insights and follow up questions.
- Ambition to have a career in science.
The salary will be in accordance with university regulations for academic personnel, and ranges from €2,379 to maximally € 3,755 per month (scale 10)
Starting date: Early 2018
Please send a detailed CV, a letter with research interests, and the names of two referees who can provide e recommendation to Martijn.Huijnen@radboudumc.nl. Closing date of for applications is 1-2-2018