Asthma is a chronic respiratory disease with increasing prevalence. Asthma cannot be cured, but some patients spontaneously enter into remission of the disease. The underlying cellular and molecular mechanisms of asthma remission are unknown. To elucidate these mechanisms, we perform an industry-sponsored translational genomics study in close collaboration with the Sanger/EMBL as part of the Open Targets program, performing single cell RNA sequencing on CD4+ T cells, ILCs and bronchial epithelial cells isolated directly from patients with active asthma, asthma remission and controls.
We have an opening for a postdoctoral research fellow, focused on bioinformatics analyses of the bronchial epithelial single-cell RNA seq data and performing functional validation experiments using matched primary epithelial cells in vitro using established methods including air-liquid interface cultures and 3D lung organoid culture models.
The project will be embedded within the Groningen Research Institute of Asthma and COPD (GRIAC), one of the 3 world’s leading translational research institutes in chronic respiratory disease. The project is part of the open targets program at Sanger/EMBL, and bio-informatic analyses will be performed in close collaboration with the Sanger team (Teichmann).
The successful candidate will hold a recent PhD degree in Molecular Biology or Life Sciences, and meets the following criteria:
- Thorough background in molecular biology and bio-informatics, as evidenced by publication record and CV.
- Team player with excellent communicative skills who can collaborate efficiently within a multidisciplinary research environment.
- Strong motivation to work towards establishing an independent research group.
- Clear interest in immunological or epithelial cell biological research.
The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.