Biological nanopores are an exciting new class of biosensors, which found practical application is in single-molecule DNA sequencing and single-molecule analysis. We have several projects in our laboratory that focus on the design and engineering of nanopores to identify specific features in single-molecules. Three main projects are:
One of the main limitation of single-molecule analysis with biological nanopore is the lack of nanopores with different size and shape. In this project, the candidate will identify and characterize nanopores with targeted diameter, shape and function.
Ideal degree: Biochemistry and biotechnology
We are part of a consortium that includes researchers from Delft and Wageningen. The candidate will develop, engineer and re-design biological nanopores that will allow the sequence identifications of proteins as they are translocated across a nanopore. This will be the first technology that will be able to identify and sequence proteins at the single-molecule level.
Ideal degree: Chemistry, Biochemistry and Biophysics
One important step in this project is to move towards real-world sample. In this project, the candidate will use the nanopores available in the laboratory to develop new methods to identify biomarkers linked to disease.
Ideal degree: Analytical chemistry, Medical science, Biophysics
Single-molecule enzymology, protein sequencing, biomarker, chemical biology, biochemistry, biophysics
This is an interdisciplinary project. The candidate may hold a PhD Degree in Chemistry, Chemical Biology, Biophysics, Biochemistry or Biotechnology or equivalent.
Expertise in molecular biology (recombinant DNA techniques, protein expression and purification), chemical modification of proteins or peptides will be an advantage, but not a limiting factor.
DEPARTMENT – Faculty of Science and Engineering
Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative institution of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 31,000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global centre of knowledge.
A postdoctoral position is available in the laboratory of Prof. Giovanni Maglia in the department of Chemistry and Biotechnology of the University of Groningen, The Netherlands. The appointment will be initially for two years and might be extended to a maximum of four years. Exceptionally motivated PhD candidates are also encouraged to apply.