← Back to list

Groningen Analytical Biochemistry Core Facility

Contact Details

University of Groningen

Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

Prof. dr. R.P.H. Bischoff, Dr. H.P. Permentier, Prof. dr. P. Horvatovich

0031 (0)50 3633338 (Bischoff) 0031 (0)50 3633341 (Horvatovich)

Hotel Description

  • Prof. Bischoff: The research group focuses on the development of innovative approaches to analyse proteins, peptides and metabolites in complex biological samples. Our main technology is based on LC-MS/MS. We collaborate closely with the group of Prof. Peter Horvatovich when it comes to data processing and data analysis. We apply this methodology primarily in the field of biomarker discovery and validation and in the analysis of biopharmaceutical proteins. Next to this we provide service to a wide range of research groups from the University of Groningen and the University Medical Center Groningen in the form of LC-MS/MS analyses for example for quantification and identification purposes.
  • Prof. Horvatovich: The research group focuses on the development of innovative processing, analysis and quality control solutions of LC-MS data to support interpretation of large-scale proteomics and metabolomics studies. My group has developed msCompare label-free LC-MS data pre-processing framework and contributed to the development of Threshold Avoiding Proteomics Pipeline to extract quantitative information from complex LC-MS proteomics and metabolomics datasets. My group has developed several innovative time alignment approaches including quality control to align complex LC-MS datasets. Currently I’m working on developing multivariate experimental design method to determine analytical factors that influence the quality of an LC-MS data and to determine and improve the accuracy of compound identification transfer between LC-MS chromatograms. In collaboration with IBM I have developed a data processing solution for MALDI Imaging data. I’m actively participating in the integration of our tools and software in Galaxy environment and building complex workflows to provide a comprehensive data processing and analysis solution for mass spectrometry based proteomics. We have experience in processing large amount of complex LC-MS in grid environment using in-house developed Data Analysis Framework, and I’m collaborating with the group of Morris Swertz to provide comprehensive solution for management and processing of large scale genomics and proteomics data. I have collaboration with the group of Dr. Henry Lam (Hong Kong University of Science and Technology) in developing an automatic data processing workflow for identification of glycopeptides and I’m actively involved a large scale international collaboration of Chromosome Centric Human Proteome Project as bioinformatics member of the Chromosome 5 team. I have close collaboration with the Biosystems Data Analysis (Prof. Age Smilde) in UvA on the statistical analysis, assessment and validation of multidimensional quantitative LC-MS data.
  • LC-MS/MS based proteomics and metabolomics;Quantitative LC-MS/MS for proteins and a wide range of other molecules
  • LC-MS based proteomics;LC-MS based metabolomics
  • Proteomics based biomarker discovery and validation;Quantitative bioanalysis of pharmaceutical proteins and peptides;Drug metabolism studies using electrochemistry
  • Mass spectrometry based differential profiling
  • Mass spectrometry based differential profiling
  • LC-MS pre-processing and statistical analysis
  • Time alignment of complex LC-MS data

Expertise and Track Record

Bischoff is the responsible scientist for the Chromosome 5 team in a large-scale international collaboration termed the Chromosome-Centric Human Proteome Project (see http://www.c-hpp.org/); Bischoff is part of the COAST consortium of NWO-ACTS. For further information see www.biomac.nl under Annual Report 2012.
Horvatovich: I’m involved as part of Chromosome 5 team in large scale international collaboration of Chromosome-Centric Human Proteome Project (see http://c-hpp.webhosting.rug.nl/tiki-index.php) developing methods for validation of eQTL results at proteomics level as well as developing comprehensive identification solution for glycopeptides (collaboration Dr. Henry Lam, University of Hong Kong).

Hotel Characteristics

No characteristics for this hotel.