Bioinformatics Group Department of Human Genetics LUMC

435002022 Characterization and quantification of maternal RNAs transferred to the child through breast milk: data ingestion via extracellular vesicles With Wauben (Utrecht University).

Most experienced in different aspects of RNA-seq data analysis in the Netherlands.
Work on the regulation of gene expression internationally widely recognized.

*A pipeline for AML diagnostics based on RNA-seq (with Haematology, GenomeScan and the Sequence Analysis Support Core)

*Analysis of smallRNAs in extracellular vesicles (with ENM Nolte-‘t Hoen, UU)

*Analysis of alternative splicing in breast cancer cell lines (with Bob vd Water, LACDR)

*RNA-seq based allele specific expression in pathogenesis of breast cancer (collaboration with LUMC’s tumorgenetics group): quality control of RNA-seq data, RNA-seq data processing, development of pipeline for analysis of differential allelic expression

*Integrative ChIP-seq and microarray-based gene expression analysis to decipher the role of Tbx3 in development of the cardiac conduction system (collaboration with AMC’s department of Anatomy and Embryology): performed microarray quality control, microarray data processing, statistical analysis of differential gene expression, ChIP-seq data quality control, preprocessing, genome alignment, advised on the calling of transcription factor binding sites and integration with expression data

BBMRI – BIOS (Biobank-based Integration of Omics Study) project on integrative analysis of methylation and expression phenotypes (member of management team)
EU – FP7 project GEUVADIS on standardization of sequencing technology and data analysis (work package coordinator and one of the main data analysts)
EU – Marie Curie International Training Network TranCYST on the study of the pathophysiological mechanisms underlying polycystic kidney disease and the prioritization of biomarkers and drug targets (work package leader)