Maastricht University Medical Center
Universiteitssingel 50 6229 ER Maastricht
Dr. M.A.M.J. van Zandvoort
0031 (0)43 3881361
The advanced optical microscopy group (headed by Marc van Zandvoort) develops and applies (for biomedical research), and keeps up-to-date a wide range of cutting-edge advanced optical microscopic equipment, such as Two-photon (resonant scanning) microscope, various confocal (resonant scanning) microscopes, Super-resolution STED (resonant scanning) microscope, and Nuance spectral microscope. The microscopes are located in a central facility (headed by Carmen Lopez-Iglesias). Of course, also basic microscopy techniques are present and supported. The group leader, Marc van Zandvoort, is appointed at several research schools in Maastricht, i.e. CARIM, NUTRIM, GROW, and MHeNS. These schools combine high-level scientific research with high-level education of young researchers, and as such are qualified as research schools by the Royal Netherlands Academy of Arts and Sciences (KNAW) and recognized as international training site for Early Stage Researchers by the European Union. The advanced optical microscopy group participates in NL-BioImaging AM (http://www.eurobioimaging.nl) and is integral part of EuroBioImaging. For contact, please go to https://gcb.mumc.nl/medewerkers/zandvoort
- Biomedical & health
- Agri & Food
- Industrial biotech
- Image analysis (Huygens, Imaris, ImagePro)
- Cardiovascular knowledge (via CARIM research school)
- Knowledge on brain imaging (Via MHeNS research school)
- Knowledge on oncology (via GROW research school)
- Knowledge on nutrition (Via Nutrim research school)
- (Multiplatform) biomedical imaging cardiovascular diseases
- idem oncological
- idem nutrition
- idem brain
- idem biomass
Expertise and Track Record
435000018 Following Enzymatic Hydrolysis of Natural Feedstock with prof. dr. H. Gruppen (WUR)
The platform uniquely combines a range of microscopic techniques, creating a platform from super-resolution imaging in living cells up to imaging at cellular resolution level in living animals. This platform can be used to image a broad range of biomedical research questions. The broad applicability and the platform structure makes this group unique. However, applications are not limited to biomedical topics. In the past we have also worked on biomass, catalysis, and agri-food, both with industrial and academic partners.
For this we refer you to https://gcb.mumc.nl/medewerkers/zandvoort, where you can find the main topics of research and the latest and updated publication list. A new website containing an overview of all the imaging techniques is under construction.
We have limited experience in the integration of microscopy with genomics and proteomics, although recently we started collaborating on this topic together with the genetics department in our faculty (imaging of genetically modified zebrafish after large scale genomics and proteomics). We have ample experience in correlating MRI with optical microscopy, Ultrasound with (intravital) optical microscopy, and PET with optical microscopy.
- https://gcb.mumc.nl/medewerkers/zandvoort will give you an overview of publications and cooperations (publication list)
- In the last round we collaborated with Wageningen University on BioMass, resulting in pubs and upcoming pubs.
NL-BioImaging-AM (MvZ is one of the members)
EuroBioImaging (MvZ is head, excellent highest ranking qualification obtained last year)
Enabling Technology (Maastricht-DSM-Limburg Province)
Dutch Society for Microscopy (member NVvM, MvZ is board member)
- 2 dedicated postdocs
- 1.5 dedicated technicians
- 1 lab manager
- 0 biostaticians, but present in University
- 0 IT-specialists, but IT knowledge is present at university evel
- Leica-TPLSM-SP5 resonant scanner and spectral/lifetime, 20x/NA0.95 objective, tunable laser for MP 680-1000 nm, 6 lines for confocal
- Leica-confocal/STED SP8, resonant scanning white light laser, range of objectives, 592 nm depletion laser
- Leica-Perkin Elmer-Nuance, allowing simultaneous imaging of up to 8 colors, range of objectives
- Range of other advanced confocal systems
- standard wide-field fluorescence and transillumination microscopes
Internal data storage on servers. Clients can take their own data from those servers.