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Department of Risk Assessment for Products in Development TNO

Contact Details

Netherlands Organisation for Applied Scientific Research TNO

Utrechtseweg 48, 3704 HE, Zeist, The Netherlands

Rob Stierum, PhD, European Registered Toxicologist

+31 (0)888661779

Hotel Description

The Research group  Risk Analysis for Products In Development (RAPID) consists of 60 experts (toxicologists, epidemiologists, immunologists, chemists, occupational hygienists, statisticians, bioinformaticians and modelers) who work in multidisciplinary projects on the assessment of health risks due to exposure to potentially hazardous chemicals and nanomaterials (NM) via the (occupational-) environment, food or drugs.

Based on scientific knowledge, RAPID develops and implements tools, models, and methods to predict these potential risks accurate and efficiently. Moreover, RAPID experts fulfill an advisory role in the design and organization of research projects, risk reduction measurements, and safe handling of chemicals. RAPID successfully applies its knowledge in the chemical, food, and pharma market. Together with universities, research institutes, government and industrial players we aim to be leading in our field. RAPID is primarily concerned with the application of in silico and desk-based research performed on data generated in collaborative (precompetitive or grant) or B2B projects.

We are engaged in PBPK modelling and systems toxicology, computational chemistry, exposure assessment and modelling, development of exposome technologies, statistics (univariate, multivariate), computational drug target safety assessment, exposure and risk assessment, safe by design concepts.

Specific expertise concerning external stressors includes industrial chemicals, asbestos, endotoxins, food allergens and reduction of exposure to dust and NM. We work within multiple industrial and (inter)national consortia/ projects where we contribute as an applied research institute, to translate research findings to applications. In addition, we often provide services or consultancy to organisations or companies. Our organisation is acclaimed for our professionalism and excellent project management.

Bioinformatics
Public
  • Agri & Food
  • Biomedical & health
  • Industrial biotech
  • Other
  • Risk Assessment & Toxicology
  • Exposure Assessment & Risk Management
  • Modelling & Statistics
  • Allergy & Risk Management
  • chemical hazard, exposure and risk assessment
  • drug development
  • food safety assessment, in particular allergens
  • Nanomaterial hazard, exposure and risk assessment
  • personalized health benefit/risk

Expertise and Track Record

Open to collaborative projects and B2B (not for profit) in the areas:

Technological expertise

  • bioinformatics
  • computational chemistry
  • computational drug target safety assessment
  • Emerging Risk Identification System/textmining
  • epidemiology
  • exposure assessment and modelling
  • exposome technologies (a.o. DIY based n=1, and sensor development)
  • life science databases
  • occupational hygiene
  • PBPK modelling
  • safe by design concepts.
  • specific expertise on industrial chemicals, asbestos, endotoxins, food allergens, dust (reduction of exposure) and NM
  • statistics (univariate, multivariate)
  • systems toxicology
  • toxicogenomics,
  • toxicoinformatics

 Biological application areas

  • chemical and NM hazard, exposure and risk assessment
  • drug development
  • food safety assessment, in particular allergens
  • personalized health and safety

RAPID was established in 2010, building further on >40 years of scientific expertise in the area of experimental toxicology, analytical chemistry, food safety, and exposure assessment. Since 15 years additional novel expertise (a.o. computational , systems biology, nanosafety, exposome) has strengthened RAPID. RAPID is involved with expertise tooling and/or databases in many collaborative and B2B (not for profit) projects, some of them are displayed in tables below. Annual turnover of 8 M€. ~60 publications annually.

As opposed to academics, TNO is an applied research institute. As a consequence, RAPID has significant expertise with (coordination of) interdisciplinary research projects across basically all outlined technologies above, including integration of different types of data-sets. These for example are:

  • exposure assessment, sensor technology development and systems biology for exposome research
  • textmining and emerging risks in food
  • the combination of in vitro toxicogenomics data with PBPK modelling;
  • systems biology data mining and drug target safety assessment;
  • exposure assessment and adaptation of occupational conditions (e.g. redesign of welding torches)
  • exposure assessment of asbestos and consultancy.
  • computational chemistry in safe by design approaches
  • Please contact us if you would like to receive references on specific expertise.

INTERNATIONAL
HBM4EU (Human Biomonitoring/Exposome)
HEALS (Exposome)
Connect4Action (Communication food related risks)
ChemScreen (Reproductive toxicology)
ART consortium (Development Advanced REACH Tool)
NanoDevice (Human exposure to nanoparticles)
MARINA (Risk management of ENM)
NanoSTAIR (Standardization for nanotechnologies)
LICARA (Life cycle analysis and risk assessment of ENM)
Dermal ART Consortium (Development Dermal Advanced REACH Tool)
NanoSolutions (Health risks of ENM)
CEN/NEN (Standardization of methodology)
BROWSE (Human exposure to pesticides)
GuideNano (Life cycle analysis of ENM)
SUN (Risk assessment of ENM)
FutureNanoNeeds (Regulatory needs for future ENM)
NANoREG (Regulatory testing of ENM)
Adaptiwall (ENM for energy efficient buildings)
Nanodata (Annual nanotechnology landscape compilation (DG Research and Innvation)
NanoReg II (Regulatory testing of ENM)
caLIBRAte (Risk assessment, management of ENM)
EUToxRisk21 (Toxicology, toxicoinformatics, innovative testing strategies)
CEFIC-AIMT2 (toxicogenomics)
CEFIC-AIMT3 (Computational toxicology)
CEFIC-AIMT4 (Computational toxicology)
POWER2DM (Predictive model-based decision support for diabetes patient empowerment)
EU FACTS (Health effects upon exposure to substances in air craft)
iFAAM (Food Allergy)
ImpARAS (Food Allergy)
SRP Food Allergy (Food Allergy)

Hotel Characteristics

  • Principal Scientist (1 fte)
  • Senior Scientists (13 fte)
  • Medior Scientists (29 fte)
  • Junior Scientists (11 fte)
  • Technicians (2 fte)

  • no specific technical physical equipment: instead many computational models for safety sciences, see above for topics

ISO 9001 certificate since 2015

Various