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Multiscale Modeling and Simulation Technology Hotel

Contact Details

Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS)

PO BOX 217

Prof. Bernard J. Geurts

0031 53 489 4125

Hotel Description

The MMS hotel has extensive expertise in computational and physical modeling of fluid-mechanical problems related to blood flow in the human body. Through the involvement of Prof. Geurts and Dr. Mikhal, direct access to high-end knowledge of modern numerical methods for CFD and large-scale computation is available. The Hotel benefits considerably from the association with the ongoing VENI project of Dr. Mikhal in which the long-term remodeling of diseased aneurysms is the key item. Beyond this in silico modeling, the contribution of Prof. Slump adds considerable expertise in medical signal analysis and in vitro modeling of flow through diseased vessels. Specifically, by exploiting recent advances in 3D printing techniques and noninvasive laser measurement methods, direct access to the flow and forces in physical reconstructions of aneurysms become available. This provides crucial reference material for a validation of computational modeling and gives insight into the general changes in blood flow that can be induced by placement of particular stents in diseased vessels.

A key strength of the MMS Hotel lies in the attention to the integration of clinical expertise into mathematical-physical modeling of human blood flow problems. Current work is directed toward developing a powerful simulation tool to

    understand blood flow in a variety of problems, i.e., stenosis in the carotid artery, stented cerebral aneurysms, and long-term stability of abdominal artery stents
    translate blood flow predictions into guidance for novel treatment devices and strategies, and supply support for clinical decision-making
Medical imaging
  • Biomedical & health
  • neurosurgery
  • tissue engineering
  • 3D printing of local vessel structures
  • blood flow in diseased regions
  • flow of air in lungs

Expertise and Track Record

43500984135 Modeling New Treatment Strategies for Intracranial Aneurysms with H.D. Boogaarts (Radboudumc)

The MMS Hotel aims to realize validated computational and physical models for human blood flow predictions. Particular attention is given to the analysis of

  • stenosis in the carotid artery
  • endovascular flow-diverter treatment of intracranial aneurysms
  • and, long-term stability of an abdominal aneurysm stent

The unique attention to clinical practice and advanced virtual and physical modeling and simulation provide novel insights into current treatment. The in silico and in vitro modeling is used toward understanding the characteristics of current treatment strategies, as well as guidance for developing future treatment strategies. Computational modeling will predict, on a patient-specific basis, the benefits of treatment with particular stents. Our approach will facilitate the selection of optimal stents ahead of any actual surgery. Our work catalyzes the development of future advanced aneurysm treatment and is open to interested Guests.

The MMS hotel combines research from Applied Mathematics and Electrical Engineering, focusing on Computational Fluid Dynamics (CFD), Medical Signals, 3D printing of local vessel structures and experimental measurement of blood flow. A number of Ph.D. projects in CFD were carried out under the supervision of MMS, with focus on method development, mathematical modeling, and flow simulation:

  • An immersed boundary method for cerebral aneurysm flow analysis
  • Euler-Euler modeling of aerosol formation and flow
  • Time-parallel simulation method for turbulent flow
  • Simulation of multiphase flows
  • Novel discretization methods for kinetic equations

In these projects, MMS contributed to supervision, research and reporting of the Ph.D. students.



Hotel Characteristics

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  • Computing cluster with 600 CPUs