Sylviusweg 72, 2333BE Leiden
Young Hae Choi
+31 71 5274510
We are experts in natural products chemistry. This includes the isolation, identification and if necessary structural elucidation of metabolites and components of diverse natural products. We specialize in plants but our experience is also extended to fungi and microorganisms.
In the last 10 years we have become a leading group in Plant Metabolomics, focusing especially on secondary metabolites profiling. We apply a metabolomic approach to diverse fields of natural product chemistry including medicinal herb quality control, plant ecology, development of antibiotics using microbes, detection of bioactive compounds in material from plants, fungi, marine products and others.
We also specialize in general phytochemical methods of isolation, identification and fractionation of natural products.
In the last 5 years, we have opened a new field of research in our group aimed at developing media for green chemistry. Our greatest achievement is the development of Natural Deep Eutectic Solvents that can completely replace or partially substitute toxic organic solvents as a media for production/extraction or conservation.
- Biomedical & health
- Structural Elucidation (Identification)
- Multivariate Data Analysis
- Plant pathogenes
- Anti-Alzheimer's disease
Expertise and Track Record
NMR identification, quality control of organisms, overal chemotaxonomy , metabolic characterisation of organisms, green chemistry for bioactive compounds.
Quality control of phytomedicines/ plant extracts for food, nutraceuticals or cosmetics.
- Under construction
Metabolomics Facility in Leiden University
- The facility has 15 current members: 6 post-docs; 5 PhD students.
- 1 technician
- 1 lab manager
30% of our turnover is related to serving third parties.
- Speed Extractor E-916 (Büchi, Switzerland) Syncore equipped with a vacuum pump V-700 (Büchi, Switzerland) ; Sepacore (MPLC system, consisting of two pump modules C-605; UV Photometer C-640; Fraction collector C-660 and Control Unit C-620 (Büchi, Switzerland); LC-Q-TOF: Ultimate 3000 UHPLC (ThermoScientific) connected to an ESI- microTOF-QII mass spectrometer (Bruker Daltonics, Germany); SFC: consisting of a1260 Infinity HPLC/DAD system equipped with a 1260 Infinity SFC Control Module (Agilent Technologies, USA). HPLC/DAD: Agilent 1200 series; equipped with a quaternary pump, autosampler and DAD (Agilent Technologies, USA) HPLC/DAD/ELSD: Agilent 1200 series, equipped with a quaternary pump, autosampler, DAD, ELSD (PL-ELS-2100; Polymer Laboratories) and fraction collector for semi-preparative HPLC. GCMS: Agilent 7890A, equipped with a 5975C inert XL MSD (Agilent Technologies, USA) GC-Q-TOF: Scion 456-GC connected to an ACPI-microTOF-QII mass spectrometer (Bruker Daltonics, Germany) GC/FID: Agilent 6890 (Agilent Technologies, USA); UV/Vis spectrophotometer 2600 (Shimadzu)