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NMR Spectroscopy Group Utrecht University

Contact Details

Utrecht University

Padualaan 8 3584 CH Utrecht

Dr. Klaartje Houben and Dr. Hans Wienk

Klaartje: +31 (0)30 2539940; Hans: +31 (0)30 2539928

Hotel Description

The research of the NMR Spectroscopy Group at the Bijvoet Center for Biomolecular Research of the Faculty of Science of Utrecht University, which also hosts the SON-NMR-Large Scale Facility (SONNMRLSF), aims to further insight into biological processes using the methods of high-resolution solution state and solid state NMR spectroscopy. Regulation of gene expression with aspects of both protein-nucleic acid interaction and protein-protein interaction is one of the research themes. The research also covers the combination of light and NMR for the analysis of photobiological processes as well as the development of new NMR methodology for structure determination, validation, the study of dynamic processes, membrane protein complexes, biomaterials, protein folding and aggregation and cellular solid state NMR.

Structural biology
  • Structural Biology
  • Molecular Biology
  • Solid-state NMR
  • Liquid-state NMR
  • Computational Biology
  • DNA-protein interactions
  • Protein-drug interactions
  • Complex biological molecules
  • Membrane-embedded proteins
  • Protein folding and aggregation

Expertise and Track Record

43500984028 Interaction of Sting with cGAMP with H. Rehmann (UMC Utrecht)

The group provides unique expertise by having the highest field NMR instruments available in the Netherlands (currently 950 and 900 MHz, later to be expanded to 1.2 GHz), and has unique expertise in NMR-analyses of biomolecules.

  • Spruijt CG, Gnerlich F, Smits AH, Pfaffeneder T, Jansen PW, Bauer C, Münzel M, Wagner M, Müller M, Khan F, Eberl HC, Mensinga A, Brinkman AB, Lephikov K, Müller U, Walter J, Boelens R, van Ingen H, Leonhardt H, Carell T, Vermeulen M. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell (2013) 152(5): 1146-59
  • Shi Y, van Steenbergen MJ, Teunissen EA, Novo L, Gradmann S, Baldus M, van Nostrum CF, Hennink WE. Π-Π Stacking Increases the Stability and Loading Capacity of Thermosensitive Polymeric Micelles for Chemotherapeutic Drugs. Biomacromolecules (2013) 14(6): 1836-37
  • Putker M, Madl T, Vos HR, de Ruiter H, Visscher M, van den Berg MC, Kaplan M, Korswagen HC, Boelens R, Vermeulen M, Burgering BM, Dansen TB. Redox-dependent control of FOXO/DAF-16 by transportin-1. Mol Cell. (2013) 49(4): 730-42
  • Koers EJ, López-Deber MP, Weingarth M, Nand D, Hickman DT, Mlaki Ndao D, Reis P, Granet A, Pfeifer A, Muhs A, Baldus M. Dynamic nuclear polarization NMR spectroscopy: revealing multiple conformations in lipid-anchored peptide vaccines. Angew Chem Int Ed Engl. (2013) 52(41): 10905-8
  • van der Cruijsen EA, Nand D, Weingarth M, Prokofyev A, Hornig S, Cukkemane AA, Bonvin AM, Becker S, Hulse RE, Perozo E, Pongs O, Baldus M. Importance of lipid-pore loop interface for potassium channel structure and function. Proc Natl Acad Sci U S A. (2013) 110(32): 13008-13
  • Renault M, Tommassen-van Boxtel R, Bos MP, Post JA, Tommassen J, Baldus M. Cellular solid-state nuclear magnetic resonance spectroscopy. Proc Natl Acad Sci U S A. (2012) 109(13): 4863-8
  • Wienk H, Slootweg JC, Speerstra S, Kaptein R, Boelens R, Folkers GE. The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition. Nucleic Acids Res. (2013) 41(13): 6739-49

The Utrecht NMR spectroscopy group is a prominent member of the Bijvoet Center that was defined as the core center for ‘Structural Biology’ in the Netherlands in the Sectorplan for Physics and Chemistry. Utrecht has been an NMR Research Infrastructure for Biomolecular NMR since 1994. At the moment the NMR group is a key member and coordinator of the EU Horizon2020-funded structural biology research initiative iNEXT. In addition, the group is involved in the EU ESFRI project INSTRUCT, an Integrated Structural Biology Infrastructure for Europe, and coordinator of the national NWO funded project uNMR-NL in the program for the National Road Map Large-scale Research Infrastructures. The group is also a member of the COAST initiative for promoting public-private collaborations in the analytical sciences.

Hotel Characteristics

  • 950 MHz (liquid state with cryoprobe/solid state NMR/micro-imaging), 900MHz ls with cryoprobe, 800 MHz ss wide-bore (wb) with DNP, 750 MHz ls, 700 MHz ss narrow-bore (nb), 600 MHz ls with cryoprobe, 600MHz ls, 500 MHz ls with laser, 500 MHz wb ss, 400 MHz wb ss with DNP