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Utrecht Centre for Medical Metabolomics

Contact Details

UMC Utrecht

UMC Utrecht, Lundlaan 6, 3584EA Utrecht

Dr. N.M. Verhoeven Duif en Prof. B. Burgering

0887555317

Hotel Description

The Utrecht Center for Medical Metabolomics is based in the UMC Utrecht, division of Biomedical Genetics. The center unites metabolic knowledge from both the diagnostic laboratory and more fundamental metabolic research. We offer a wide range of analyses for biomedical research and have a great number of collaborations.

Metabolomics
Public
  • Agri & Food
  • Biomedical & health
  • Bio informatics
  • Metabolism
  • Oncology
  • Neurology

Expertise and Track Record

Unique analyses:
– Vitamin B6 vitamers
– D-amino acids and other enantiomer-selective analyses
– Krebs cycle & related metabolites platform
– Direct infusion mass spectrometry

Expert knowledge on
– Vitamin B6 metabolism
– Cancer metabolism & regulation
– Amino acid metabolism
– Regulation of energy metabolism

Recent and current projects:
– biochemical characterisation of knock-out mice
– biochemical characterisation of knock-out drosophila
– metabolic studies in zebra fish larvae

We have several projects on the functional characterisation of novel genetic variants that were found by next generation sequencing (whole exome sequencing).

  • D-amino acid aberrations in cerebrospinal fluid and plasma of smokers. PMID:23615666
  • Development and validation of a quantitative LC-tandem MS assay for hexadeca-4,7,10,13-tetraenoic acid in human and mouse plasma. PMID:23502461

Utrecht Life sciences: provision of metabolomics technology

Hotel Characteristics

  • 2 principlal investigators, 4 post docs, 1 bio infomatician, 6 technicians, 1 labamager

5%

  • Waters: Xevo with UPLC; UPLC-Ultima. Thermo: Q-exactive plus. & LTQ-Orbitrap-XL; GC-MS

ISO15189

No